General Transcription Factor IIH (TFIIH) as a Drug Target: A Review

Target Name: General transcription factor IIH

NCBI ID: P17887

General transcription factor IIH

Other Name(s): TFIIH basal transcription factor complex | TFIIH

General Transcription Factor IIH (TFIIH) as a Drug Target: A Review

Abstract:
General transcription factor IIH (TFIIH) is a key regulator of gene expression, involved in the control of cell cycle progression and the regulation of cell survival. The TFIIH complex plays a crucial role in the regulation of transcription initiation, DNA replication, and DNA damage repair processes. TFIIH has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a drug target, TFIIH is a promising target for small molecule inhibitors that can be used to treat these diseases. This review summarizes the current understanding of TFIIH as a drug target and discusses the potential therapeutic benefits and challenges.

Introduction:
Transcription is a critical process in gene expression, where RNA polymerase II (RNA-P2) uses a template DNA strand to generate a functional RNA molecule. Transcription is regulated by various factors, including the TFIIH complex. The TFIIH complex is a protein complex that consists of the core factors TFIIH1 and TFIIH2, and several additional non-core factors. The TFIIH1-GFP complex is responsible for the regulation of DNA replication, while the TFIIH2-GFP complex is involved in the regulation of the cell cycle.

TFIIH has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, TFIIH has been shown to be involved in the regulation of cancer cell growth and progression. In addition, TFIIH has been implicated in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

TFIIH has also been shown to play a role in the regulation of DNA damage repair processes. This is important for the regulation of cell survival and the prevention of diseases such as DNA double-strand break repair disorders.

As a drug target, TFIIH is a promising target for small molecule inhibitors that can be used to treat these diseases. This review summarizes the current understanding of TFIIH as a drug target and discusses the potential therapeutic benefits and challenges.

Current Theories on TFIIH as a Drug Target:
TFIIH has been shown to be involved in the regulation of various cellular processes, including cell cycle progression, DNA replication, and DNA damage repair. This suggests that TFIIH may be a potential drug target for diseases that are characterized by the disruption of these processes.

One of the main targets of TFIIH is the regulation of DNA replication. TFIIH has been shown to play a role in the regulation of DNA replication by allowing the movement of the TFIIH1-GFP complex to the replication complex. This movement is important for the proper functioning of DNA replication and may be a potential target for small molecule inhibitors.

TFIIH has also been shown to play a role in the regulation of the cell cycle. TFIIH has been shown to allow the movement of the TFIIH2-GFP complex to the metaphysical region of the cell cycle, where the replication complex is assembled. This movement is important for the proper functioning of the cell cycle and may be a potential target for small molecule inhibitors.

In addition to its role in the regulation of DNA replication and the cell cycle, TFIIH has also been shown to play a role in the regulation of DNA damage repair processes. This is important for the regulation of cell survival and the prevention of diseases such as DNA double-strand break repair disorders.

Potential Therapeutic Benefits of TFIIH as a

Protein Name: General Transcription Factor IIH

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•   general information;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
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